The religion of Islam believes in the principle of saving human lives. The Moslem Religious Council initially rejected organ donation by followers of Islam in 1983; but it has reversed its position, provided that donors consent in writing in advance. The organs of Moslem donors must be transplanted immediately and not stored in organ banks. According to Dr. Abdel-Rahman Osman, Director of the Muslim Community Center in Maryland, "We have no policy against organ donation as long as it is done with respect for the deceased and for the benefit of the recipient." In addition, according to A. Sachedina in his Transplantation Proceedings' (1990) article, Islamic Views on Organ Transplantation, "...the majority of the Muslim scholars belonging to various schools of Islamic law have invoked the principle of priority of saving human life and have permitted the organ transplant as a necessity to procure that noble end."

According to the Watch Tower Society, the legal corporation for the religion, Jehovah's Witnesses believe donation is a matter of individual decision. Jehovah's Witnesses are often assumed to be opposed to donation because of their belief against blood transfusion. However, this merely means that all blood must be removed from the organs and tissues before being transplanted.

Judaism teaches that saving a human life takes precedence over maintaining the sanctity of the human body. A direct transplant is preferred, however. According to Orthodox Rabbi Moses Tendler, Chairman of the Biology Department of Yeshiva University in New York City and Chairman of the Bioethics Commission of the Rabbinical Council of America, "If one is in the position to donate an organ to save another's life, it's obligatory to do so, even if the donor never knows who the beneficiary will be. The basic principle of Jewish ethics - 'the infinite worth of the human being' - also includes donation of corneas, since eyesight restoration is considered a life-saving operation." He adds, "It is given that the donor must be brain dead in accordance with the standards set by the Harvard University criteria and the President's Commission on brain death. Organ donation is actually a 'moral obligation'". It is the only "mitzvah" or good deed, an individual can perform after death. Rabbi Tendler acknowledged that there is still some reluctance regarding organ donating among Hassidic Jews due to concerns about "defilement of the dead." Conservative and Reformed Jews may accept brain death more easily than will Orthodox and Hassidic Jews. In 1991, the Rabbinical Council of America (Orthodox) approved organ donations as permissible, and even required, from brain-dead patients. The Reform movement looks upon the transplant program favorably and Rabbi Richard Address, Director of the Union of American Hebrew Congregations Bio-Ethics Committee and Committee on Older Adults, states that "Judaic Response materials provide a positive approach and by and large the North American Reform Jewish community approves of transplantation."

In 1984, the Lutheran Church in America passed a resolution stating that donation contributes to the well-being of humanity and can be "...an expression of sacrificial love for a neighbor in need." They call on members to consider donating organs and to make any necessary family and legal arrangements, including the use of a signed donor card. According to Rev. James W. Rassbach of the Board for Communication Services, Missouri-Synod, "We believe that our Lord Christ came to give life and came to give it in abundance. Organ donation enables more abundant life, alleviates pain and suffering and is an expression of love in times of tragedy."

Mennonites have no formal position on donation, but are not opposed to it. They believe the decision to donate is up to the individual and/or his or her family.